SrasV1, Main, Exploration, bibRecord, 003194

Ribavirin Reduces Mortality in Enterovirus 71–Infected Mice by Decreasing Viral Replication

Identifieur interne : 003194 ( Main/Exploration ); précédent : 003193; suivant : 003195

Ribavirin Reduces Mortality in Enterovirus 71–Infected Mice by Decreasing Viral Replication

Auteurs : Zhao-Hong Li ; Chien-Ming Li [République populaire de Chine] ; Pin Ling ; Fang-Hsiu Shen [République populaire de Chine] ; Shih-Heng Chen [République populaire de Chine] ; Ching-Chuan Liu [République populaire de Chine] ; Chun-Keung Yu ; Shun-Hua Chen [République populaire de Chine, Taïwan]

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2008.

RBID : ISTEX:5B7F21B5C7B9CCDAA6F70BC7F834E477CD9C5603

Abstract

Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC50 of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug

Url:

https://api.istex.fr/ark:/67375/HXZ-MCLFVVBS-C/fulltext.pdf

DOI: 10.1086/527326

Affiliations:

République populaire de Chine, Taïwan

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Le document en format XML

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Ribavirin Reduces Mortality in Enterovirus 71–Infected Mice by Decreasing Viral Replication

Ribavirin Reduces Mortality in Enterovirus 71–Infected Mice by Decreasing Viral Replication

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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